MIF-1 vial (50mg)

Ceretropic MIF-1 vial (50mg)


What is MIF-1?

MIF-1 (melanocyte-stimulating hormone release-inhibiting factor-1) is a peptide hormone derived from the cleavage of the hormone oxytocin. It is known to block alpha-MSH (alpha-melanocyte-stimulating hormone) which is a full agonist of the melanocortin receptors MC1, MC3, MC4 and MC5.

Studies have shown that the melanocortin system can play an important role in the pathology of anhedonia. According to a Stanford article, such ‘synaptic adaptations’ occur due to the increase of melanocortin hormones (i.e. alpha-MSH). Since MIF-1 blocks alpha-MSH, MIF-1 also blocks “MC4 receptor-mediated synaptic adaptations” and thus can prevent stress induced anhedonia. It also acts as a positive allosteric modulator of D2R.

A double-blind 28-day study was conducted to compare the antidepressant efficacy of MIF-1 with the antidepressant Imipramine. Twenty patients suffering from major depression participated. Clinical responses were measured by using various depression rating scales. The results indicate that MIF-I was at least as effective as Imipramine in this study.

However, the most impressive and significant study on MIF-1 is the one by Rudolph H. Ehrensing and Abba J. Kastin in 1994. In this double-blind pilot study, involving 20 patients with significant depression who met the DSM-III-R criteria for major depression, who received a subcutaneous injection of either 50mg of MIF-1 (Pro-Leu-Gly-NH2) or a placebo for five consecutive days. At the end of the first week, the group that received MIF-1 improved significantly on all rating scales compared with the group that received the placebo. Eight out of nine patients who received MIF-1 showed a marked improvement compared with only two of the eleven patients who received a placebo. Administration of MIF-1 during the second week to patients who had received a placebo during the first week, resulted in a substantial improvement.

MIF-1 benefits

  • Can improve mood and reduce anhedonia.
  • Can reduce stress and depression.

Product presentation

MIF-1 vial (50mg).

Scientific studies


This product has not been evaluated by the FDA and is not intended to diagnose, cure, or prevent any disease.

Safety Information: Keep this product out of the reach of children. This product is not a dietary supplement. It is a research compound, sold as a raw material. It may result in adverse effects if improperly handled or consumed. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material.

Cymnootropics.com can’t be held responsible for any adverse effects that may arise from improper handling and/or consumption of this product.


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