What is MIF-1?
MIF-1 (melanocyte-stimulating hormone release-inhibiting factor-1) is a peptide hormone derived from the cleavage of the hormone oxytocin. It is known to block alpha-MSH (alpha-melanocyte-stimulating hormone) which is a full agonist of the melanocortin receptors MC1, MC3, MC4 and MC5.
Studies have shown that the melanocortin system can play an important role in the pathology of anhedonia. According to a Stanford article, such ‘synaptic adaptations’ occur due to the increase of melanocortin hormones (i.e. alpha-MSH). Since MIF-1 blocks alpha-MSH, MIF-1 also blocks “MC4 receptor-mediated synaptic adaptations” and thus can prevent stress induced anhedonia. It also acts as a positive allosteric modulator of D2R.
A double-blind 28-day study was conducted to compare the antidepressant efficacy of MIF-1 with the antidepressant Imipramine. Twenty patients suffering from major depression participated. Clinical responses were measured by using various depression rating scales. The results indicate that MIF-I was at least as effective as Imipramine in this study.
However, the most impressive and significant study on MIF-1 is the one by Rudolph H. Ehrensing and Abba J. Kastin in 1994. In this double-blind pilot study, involving 20 patients with significant depression who met the DSM-III-R criteria for major depression, who received a subcutaneous injection of either 50mg of MIF-1 (Pro-Leu-Gly-NH2) or a placebo for five consecutive days. At the end of the first week, the group that received MIF-1 improved significantly on all rating scales compared with the group that received the placebo. Eight out of nine patients who received MIF-1 showed a marked improvement compared with only two of the eleven patients who received a placebo. Administration of MIF-1 during the second week to patients who had received a placebo during the first week, resulted in a substantial improvement.
- Can improve mood and reduce anhedonia.
- Can reduce stress and depression.
MIF-1 vial (50mg).
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